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OPRL1 antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P79292 |
| Other Accession | NM_182647, NP_872588 |
| Reactivity | Human, Mouse, Rat, Rabbit, Pig, Goat, Sheep, Horse, Bovine, Guinea Pig, Dog |
| Predicted | Human, Mouse, Rat, Chicken, Bovine, Guinea Pig, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 41kDa |
| Gene ID | 397364 |
|---|---|
| Alias Symbol | KOR-3, MGC34578, NOCIR, OOR, ORL1 |
| Other Names | Nociceptin receptor, K3 opiate receptor, Kappa-type 3 opioid receptor, KOR-3, ORGC, Orphanin FQ receptor, OPRL1 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-OPRL1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | OPRL1 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | OPRL1 |
|---|---|
| Function | G-protein coupled opioid receptor that functions as a receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle. Note=Ligand binding leads to receptor internalization into cytoplasmic vesicles, decreasing the amount of available receptor at the cell surface Internalization requires phosphorylation at Ser-363. Can recycle to the cell membrane (By similarity). |
| Tissue Location | Detected in brain cortex, stomach, ileum, jejunum and colon. |
Citations (0)
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
Submit your citation using an Abcepta antibody to
info@abcepta.com, and receive a free "I Love Antibodies" mug.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Osinski M.A.,et al.Eur. J. Pharmacol. 365:281-289(1999).
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$ 389.00
Cat# AI14423
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