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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Opn3 antibody - C-terminal region   

Opn3 antibody - C-terminal region

Rabbit Polyclonal Antibody

     
  • WB - Opn3 antibody - C-terminal region AI14464

    WB Suggested Anti-Opn3 Antibody Titration: 1.0 μg/ml
    Positive Control: Mouse Small Intestine
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q9WUK7
Other Accession NM_010098, NP_034228
Reactivity Human, Mouse, Rat, Rabbit, Horse, Guinea Pig, Dog
Predicted Human, Mouse, Rat, Rabbit, Chicken, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 45kDa
Additional Information
Gene ID 13603
Alias Symbol ERO, Ecpn, MGC124138, panopsin
Other Names Opsin-3, Encephalopsin, Panopsin, Opn3, Ecpn
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-Opn3 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsOpn3 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Opn3
Synonyms Ecpn
Function G-protein coupled receptor which selectively activates G proteins via ultraviolet A (UVA) light-mediated activation in the skin (PubMed:30284927). Binds both 11-cis retinal and all-trans retinal (By similarity). Regulates melanogenesis in melanocytes via inhibition of alpha-MSH-induced MC1R-mediated cAMP signaling, modulation of calcium flux, regulation of CAMK2 phosphorylation, and subsequently phosphorylation of CREB, p38, ERK and MITF in response to blue light (By similarity). Plays a role in melanocyte survival through regulation of intracellular calcium levels and subsequent BCL2/RAF1 signaling (By similarity). Additionally regulates apoptosis via cytochrome c release and subsequent activation of the caspase cascade (By similarity). Required for TYR and DCT blue light-induced complex formation in melanocytes (By similarity). Involved in keratinocyte differentiation in response to blue-light (By similarity). Required for the UVA- mediated induction of calcium and mitogen-activated protein kinase signaling resulting in the expression of MMP1, MMP2, MMP3, MMP9 and TIMP1 in dermal fibroblasts (By similarity). Plays a role in light- mediated glucose uptake, mitochondrial respiration and fatty acid metabolism in brown adipocyte tissues (PubMed:32040503). May be involved in photorelaxation of airway smooth muscle cells, via blue- light dependent GPCR signaling pathways (PubMed:30284927).
Cellular Location Cell membrane {ECO:0000250|UniProtKB:Q9H1Y3}; Multi-pass membrane protein. Cytoplasm {ECO:0000250|UniProtKB:Q9H1Y3}
Tissue Location Expressed in the eye (at protein level) (PubMed:30284927). Expressed in tracheal airway smooth muscle (PubMed:30284927). Expressed in brown adipocyte tissue; expression becomes more abundant during differentiation (PubMed:32040503) Strongly expressed in brain (PubMed:10234000). Highly expressed in the preoptic area and paraventricular nucleus of the hypothalamus (PubMed:10234000). Shows highly patterned expression in other regions of the brain, being enriched in selected regions of the cerebral cortex, cerebellar Purkinje cells, a subset of striatal neurons, selected thalamic nuclei, and a subset of interneurons in the ventral horn of the spinal cord (PubMed:10234000)
Research Areas
Citations (0)

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References

Blackshaw S.,et al.J. Neurosci. 19:3681-3690(1999).
Kasper G.,et al.Gene 295:27-32(2002).
Carninci P.,et al.Science 309:1559-1563(2005).

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$ 389.00
Cat# AI14464
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