Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
Aplnr antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9WV08 |
| Other Accession | NM_011784, NP_035914 |
| Reactivity | Human, Mouse, Rat, Rabbit, Horse, Dog |
| Predicted | Human, Mouse, Rabbit |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 42kDa |
| Gene ID | 23796 |
|---|---|
| Alias Symbol | APJ, Agtrl1, msr/apj |
| Other Names | Apelin receptor, Angiotensin receptor-like 1, G-protein coupled receptor APJ, MSR, Aplnr, Agtrl1, Apj |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Aplnr antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Aplnr antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Aplnr {ECO:0000312|MGI:MGI:1346086} |
|---|---|
| Synonyms | Agtrl1, Apj |
| Function | G protein-coupled receptor for peptide hormones apelin (APLN) and apelin receptor early endogenous ligand (APELA), that plays a role in the regulation of normal cardiovascular function and fluid homeostasis (PubMed:22810587, PubMed:28663440, PubMed:28854362, PubMed:28890073). When acting as apelin receptor, activates both G(i) protein pathway that inhibits adenylate cyclase activity, and the beta- arrestin pathway leading to internalization of the receptor (PubMed:22810587, PubMed:28663440, PubMed:28854362, PubMed:28890073). APLNR/APJ receptor is also activated by mechanical strech in a G- protein-independent fashion to induce beta-arrestin signaling leading to cardiac hypertrophy (PubMed:22810587). However, the presence of apelin ligand blunts cardiac hypertrophic induction from APLNR/APJ on response to pathological stimuli (PubMed:22810587). Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for APELA hormone (PubMed:28663440, PubMed:28854362, PubMed:28890073). May promote angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis (By similarity). Promotes sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel development (PubMed:28890073). Also plays a role in various processes in adults such as regulation of blood vessel formation, blood pressure and heart contractility and protection from cardiac hypertrophy and heart failure (PubMed:22810587, PubMed:28371822). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:P35414}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P79960}. Note=After exposure to apelin (APLN) or apelin receptor early endogenous ligand (APELA), internalized from the cell surface into an endosomal recycling compartment, from where it is recycled to the cell membrane {ECO:0000250|UniProtKB:P35414, ECO:0000250|UniProtKB:Q9JHG3} |
| Tissue Location | Expressed in coronary endothelial cells (at protein level) (PubMed:28890073). Expressed in the embryo, allantoic and endothelial precursor cells of the yolk sac at 8 days post-coitum (dpc) (PubMed:28663440). Expressed in the secondary heart field and somite at 8.25 dpc (PubMed:28854362). Expressed in fetal allantoic endothelial cells at 9 dpc (PubMed:28663440). Expressed in the allantoid and the invading fetal vasculature of the placenta at 9.5 dpc (PubMed:28854362). Expressed in endothelial cells adjacent to syncytiotrophoblast cells at 10.5 dpc (PubMed:28663440). Expressed weakly in the embryonic heart at 11.5 dpc (PubMed:26611206). Expressed in the adult heart (PubMed:26611206). Expressed in endothelial cells and cardiomyocytes and weakly expressed in fibroblasts (PubMed:10473142, PubMed:26611206). |
Research Areas
Citations (0)
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
Submit your citation using an Abcepta antibody to
info@abcepta.com, and receive a free "I Love Antibodies" mug.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Devic E.,et al.Mech. Dev. 84:199-203(1999).
Carninci P.,et al.Science 309:1559-1563(2005).
Abcepta welcomes feedback from its customers.
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
$ 389.00
Cat# AI14483
Ordering Information
United States
AlbaniaAustraliaAustriaBelgiumBosnia & HerzegovinaBrazilBulgariaCanadaCentral AmericaChinaCroatiaCyprusCzech RepublicDenmarkEstoniaFinlandFranceGermanyGreeceHong KongHungaryIcelandIndiaIndonesiaIrelandIsraelItalyJapanLatviaLithuaniaLuxembourgMacedoniaMalaysiaMaltaMexicoNetherlandsNew ZealandNorwayPakistanPolandPortugalRomaniaSerbiaSingaporeSlovakiaSloveniaSouth AfricaSouth KoreaSpainSwedenSwitzerlandTaiwanTurkeyUnited KingdomUnited StatesVietnamWorldwideOthers
USA Headquarters
(888) 735-7227 / (858) 622-0099 or (858) 875-1900
Other Products
Shipping Information
Domestic orders (in stock items)
Shipped out the same day. Orders placed after 1 PM (PST) will ship out the next business day.
International orders
Contact your local distributors
