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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   ACER1 antibody - C-terminal region   

ACER1 antibody - C-terminal region

Rabbit Polyclonal Antibody

     
  • WB - ACER1 antibody - C-terminal region AI14573

    WB Suggested Anti-ACER1 Antibody Titration: 1.0 μg/ml
    Positive Control: Fetal Brain
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q8TDN7
Other Accession NM_133492, NP_597999
Reactivity Human
Predicted Human
Host Rabbit
Clonality Polyclonal
Calculated MW 31kDa
Additional Information
Gene ID 125981
Alias Symbol ASAH3, MGC138327, MGC138329, ALKCDase1
Other Names Alkaline ceramidase 1, AlkCDase 1, Alkaline CDase 1, 3.5.1.23, Acylsphingosine deacylase 3, N-acylsphingosine amidohydrolase 3, ACER1, ASAH3
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-ACER1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsACER1 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ACER1 (HGNC:18356)
Synonyms ASAH3
Function Endoplasmic reticulum ceramidase that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids at alkaline pH (PubMed:17713573, PubMed:20207939, PubMed:20628055). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:12783875). Exhibits a strong substrate specificity towards the natural stereoisomer of ceramides with D-erythro-sphingosine as a backbone and has a higher activity towards very long-chain unsaturated fatty acids like the C24:1-ceramide (PubMed:17713573, PubMed:20207939). May also hydrolyze dihydroceramides to produce dihydrosphingosine (PubMed:20207939, PubMed:20628055). ACER1 is a skin-specific ceramidase that regulates the levels of ceramides, sphingosine and sphingosine-1-phosphate in the epidermis, mediates the calcium-induced differentiation of epidermal keratinocytes and more generally plays an important role in skin homeostasis (PubMed:17713573).
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein
Tissue Location Mainly expressed in epidermis.
Research Areas
Citations (0)

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References

Mao C.,et al.J. Biol. Chem. 278:31184-31191(2003).
Houben E.,et al.J. Lipid Res. 47:1063-1070(2006).

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$ 389.00
Cat# AI14573
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