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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CP4F8 Antibody - middle region   

CP4F8 Antibody - middle region

Rabbit Polyclonal Antibody

     
  • WB - CP4F8 Antibody - middle region AI14578

    Host: Rabbit
    Target Name: CP4F8
    Sample Tissue: 786-0 Whole Cell lysates
    Antibody Dilution: 1.0μg/ml
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P98187
Reactivity Human
Predicted Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 57kDa
Additional Information
Gene ID 11283
Alias Symbol CYP4F8,
Other Names Cytochrome P450 4F8, 1.14.14.1, CYPIVF8, CYP4F8
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 &mu, l of distilled water. Final Anti-CP4F8 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
PrecautionsCP4F8 Antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CYP4F8 {ECO:0000303|PubMed:10791960, ECO:0000312|HGNC:HGNC:2648}
Function A cytochrome P450 monooxygenase involved in the metabolism of endogenous polyunsaturated fatty acids (PUFAs) and their oxygenated derivatives (oxylipins). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds, with preference for omega-1 and omega-2 positions (PubMed:10791960, PubMed:16112640, PubMed:15789615). Hydroxylates (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) predominantly at omega-2 position to form (18R)- hydroxyeicosatetraenoic acid (18R-HETE) (PubMed:10791960). Exhibits omega-1 hydroxylase activity toward prostaglandin (PG) H1, PGH2 and PGI2 (PubMed:10791960, PubMed:15789615). Catalyzes the epoxidation of double bonds of PUFAs, including docosahexaenoic and docosapentaenoic acids (PubMed:16112640). Shows little activity against PGD2, PGE1, PGE2, PGF2alpha, and leukotriene B4.
Cellular Location Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9HBI6}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9HBI6}. Microsome membrane {ECO:0000250|UniProtKB:Q9HBI6}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9HBI6}
Tissue Location Expressed in the epithelium of seminal vesicles, in renal cortex, in adult and fetal liver, in epidermis, in corneal epithelium, in sweat glands, hair follicles, epithelial linings of the ampulla of vas deferens and of the stomach and small intestine, as well as in the transitional epithelium of the bladder and ureter (at protein level). In the epidermis, expressed from the basal cell to the granular cell layers. In the corneal epithelium, expressed in all cell layers Also detected in prostate. Up-regulated in the epidermis of psoriatic lesions.
Research Areas
Citations (0)

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References

Bylund J.,et al.Biochem. Biophys. Res. Commun. 261:169-174(1999).
Bylund J.,et al.J. Biol. Chem. 275:21844-21849(2000).
Stark K.,et al.Arch. Biochem. Biophys. 409:188-196(2003).
Stark K.,et al.Arch. Biochem. Biophys. 441:174-181(2005).
Stark K.,et al.Prostaglandins Other Lipid Mediat. 75:47-64(2005).

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$ 389.00
Cat# AI14578
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