|Other Accession||NM_009810, NP_033940|
|Reactivity||Human, Rat, Pig, Goat, Sheep, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Rat, Pig, Goat, Sheep, Horse, Bovine, Guinea Pig, Dog|
|Alias Symbol||A830040C14Rik, AC-3, Apopain, CC3, CPP32, Caspase-3, Lice, Yama, mldy|
|Other Names||Caspase-3, CASP-3, 220.127.116.11, Apopain, Cysteine protease CPP32, CPP-32, LICE, Protein Yama, SREBP cleavage activity 1, SCA-1, Caspase-3 subunit p17, Caspase-3 subunit p12, Casp3, Cpp32|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Casp3 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Casp3 Antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes.|
|Tissue Location||Highest expression in spleen, lung, liver, kidney and heart. Lower expression in brain, skeletal muscle and testis|
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Provided below are standard protocols that you may find useful for product applications.
Juan T.S.-C.,et al.Oncogene 13:749-755(1996).
Mukasa T.,et al.Biochem. Biophys. Res. Commun. 231:770-774(1997).
van de Craen M.,et al.FEBS Lett. 403:61-69(1997).
Fernandes-Alnemri T.,et al.Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases.
Denis F.,et al.Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases.
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