Casp3 Antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application ![]()
| WB |
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Primary Accession | P70677 |
Other Accession | NM_009810, NP_033940 |
Reactivity | Human, Rat, Pig, Goat, Sheep, Horse, Bovine, Guinea Pig, Dog |
Predicted | Human, Rat, Pig, Goat, Sheep, Horse, Bovine, Guinea Pig, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 31kDa |
Gene ID | 12367 |
---|---|
Alias Symbol | A830040C14Rik, AC-3, Apopain, CC3, CPP32, Caspase-3, Lice, Yama, mldy |
Other Names | Caspase-3, CASP-3, 3.4.22.56, Apopain, Cysteine protease CPP32, CPP-32, LICE, Protein Yama, SREBP cleavage activity 1, SCA-1, Caspase-3 subunit p17, Caspase-3 subunit p12, Casp3, Cpp32 |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Casp3 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | Casp3 Antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Casp3 |
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Synonyms | Cpp32 |
Function | Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. |
Cellular Location | Cytoplasm. |
Tissue Location | Highest expression in spleen, lung, liver, kidney and heart. Lower expression in brain, skeletal muscle and testis |

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Provided below are standard protocols that you may find useful for product applications.
References
Juan T.S.-C.,et al.Oncogene 13:749-755(1996).
Mukasa T.,et al.Biochem. Biophys. Res. Commun. 231:770-774(1997).
van de Craen M.,et al.FEBS Lett. 403:61-69(1997).
Fernandes-Alnemri T.,et al.Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases.
Denis F.,et al.Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases.

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