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HEXA antibody - C-terminal region

Rabbit Polyclonal Antibody

     
  • IHC - HEXA antibody - C-terminal region AI14612
    Immunohistochemistry with Brain, cortex tissue at an antibody concentration of 5μg/ml using anti-HEXA antibody (AI14612)
  • WB - HEXA antibody - C-terminal region AI14612

    WB Suggested Anti-HEXA Antibody Titration: 1 μg/ml
    Positive Control: Fetal kidney lysate
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC
Primary Accession P06865
Other Accession NM_000520, NP_000511
Reactivity Human, Mouse, Rat, Rabbit, Pig, Sheep, Horse, Bovine, Guinea Pig, Dog
Predicted Human, Mouse, Rat, Rabbit, Pig, Sheep, Horse, Bovine, Guinea Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 48kDa
Additional Information
Gene ID 3073
Alias Symbol MGC99608, TSD
Other Names Beta-hexosaminidase subunit alpha, 3.2.1.52, Beta-N-acetylhexosaminidase subunit alpha, Hexosaminidase subunit A, N-acetyl-beta-glucosaminidase subunit alpha, HEXA
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-HEXA antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsHEXA antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HEXA (HGNC:4878)
Function Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides (PubMed:11707436, PubMed:9694901, PubMed:8672428, PubMed:8123671). The isozyme S is as active as the isozyme A on the anionic bis-sulfated glycans, the chondroitin-6- sulfate trisaccharide (C6S-3), and the dermatan sulfate pentasaccharide, and the sulfated glycosphingolipid SM2 (PubMed:11707436). The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide (PubMed:11707436). Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A (PubMed:9694901, PubMed:8672428, PubMed:8123671).
Cellular Location Lysosome.
Research Areas
Citations (0)

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References

Myerowitz R.,et al.Proc. Natl. Acad. Sci. U.S.A. 82:7830-7834(1985).
Proia R.L.,et al.J. Biol. Chem. 262:5677-5681(1987).
Triggs-Raine B.L.,et al.Am. J. Hum. Genet. 49:1041-1054(1991).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.

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$ 389.00
Cat# AI14612
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