DHPS antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | P49366 |
Other Accession | NM_013406, NP_037538 |
Reactivity | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog |
Predicted | Human, Mouse, Horse, Guinea Pig, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 35kDa |
Gene ID | 1725 |
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Alias Symbol | MIG13, DS, DHS |
Other Names | Deoxyhypusine synthase, DHS, 2.5.1.46, DHPS, DS |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-DHPS antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | DHPS antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | DHPS |
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Synonyms | DS |
Function | Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue (PubMed:30661771). This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function. |
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Provided below are standard protocols that you may find useful for product applications.
References
Joe Y.A.,et al.J. Biol. Chem. 270:22386-22392(1995).
Bevec D.,et al.FEBS Lett. 378:195-198(1996).
Yan Y.P.,et al.Biochem. J. 315:429-434(1996).
Mantuano E.,et al.Gene 215:153-157(1998).
Yu W.,et al.Genome Res. 7:353-358(1997).
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