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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Mapre1 antibody - C-terminal region   

Mapre1 antibody - C-terminal region

Rabbit Polyclonal Antibody

     
  • WB - Mapre1 antibody - C-terminal region AI14714

    WB Suggested Anti-Mapre1 Antibody Titration: 1.0 μg/ml
    Positive Control: Mouse Spleen
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q61166
Other Accession NM_007896, NP_031922
Reactivity Human, Mouse, Rat, Rabbit, Goat, Horse, Bovine, Guinea Pig, Dog
Predicted Mouse, Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 30kDa
Additional Information
Gene ID 13589
Alias Symbol 5530600P05Rik, AI462499, AI504412, AW260097, BIM1p, D2Ertd459e, Eb1
Other Names Microtubule-associated protein RP/EB family member 1, APC-binding protein EB1, End-binding protein 1, EB1, Mapre1
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-Mapre1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsMapre1 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Mapre1
Function Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules. Acts as a regulator of autophagosome transport via interaction with CAMSAP2 (By similarity). May play a role in cell migration (PubMed:15311282).
Cellular Location Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q15691}. Note=Associated with the microtubule network at the growing distal tip of microtubules (PubMed:21357749) Also enriched at the centrosome (By similarity) {ECO:0000250|UniProtKB:Q15691, ECO:0000269|PubMed:21357749}
Tissue Location Expressed within the midpiece of sperm tail (at protein level).
Research Areas
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References

Sparks A.B.,et al.Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.
Bienvenut W.V.,et al.Submitted (FEB-2008) to UniProtKB.
Wen Y.,et al.Nat. Cell Biol. 6:820-830(2004).
Wu X.,et al.Cell 135:137-148(2008).
Fong K.W.,et al.Mol. Biol. Cell 20:3660-3670(2009).

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$ 389.00
Cat# AI14714
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