|Other Accession||NM_001098525, NP_001091995|
|Reactivity||Human, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Pig, Horse, Bovine, Dog|
|Alias Symbol||DKFZp686L1238, FLJ10749, LB1, TMAP, se20-10|
|Other Names||Cytoskeleton-associated protein 2, CTCL tumor antigen se20-10, Tumor- and microtubule-associated protein, CKAP2 (HGNC:1990)|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-CKAP2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||CKAP2 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53- dependent manner (By similarity).|
|Cellular Location||Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Contrary to the ectopically expressed protein, endogenous CKAP2 does not colocalize with microtubules in G1, S and early G2. At late G2 and prophase after separation of duplicated centrosomes, colocalizes with gamma-tubulin and centrosome-proximal microtubules. From prometaphase through anaphase B, colocalizes with mitotic spindle poles and spindle microtubules. During cytokinesis, absent from midbody microtubules|
|Tissue Location||Abundant in testis, thymus, and in tumor derived cell lines, while barely detectable in liver, prostate, and kidney|
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Provided below are standard protocols that you may find useful for product applications.
Maouche-Chretien L.,et al.Oncogene 17:1245-1251(1998).
Udina I.G.,et al.Genetika 37:120-123(2001).
Bae C.-D.,et al.J. Cancer Res. Clin. Oncol. 129:621-630(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
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