Pacsin3 antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q99JB8 |
Other Accession | NM_028733, NP_083009 |
Reactivity | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog |
Predicted | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 48kDa |
Gene ID | 80708 |
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Alias Symbol | 4921507A02Rik, 6330413E15Rik, AW413130 |
Other Names | Protein kinase C and casein kinase II substrate protein 3, Pacsin3 |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Pacsin3 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | Pacsin3 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Pacsin3 |
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Function | Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity. |
Cellular Location | Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Detected at the inner aspect of the plasma membrane in myotubes |
Tissue Location | Highly expressed in skeletal muscle, heart and lung; also detected in brain, kidney and uterus (at protein level) |
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Provided below are standard protocols that you may find useful for product applications.
References
Modregger J.,et al.J. Cell Sci. 113:4511-4521(2000).
Sumoy L.,et al.Gene 262:199-205(2001).
Cuajungco M.P.,et al.J. Biol. Chem. 281:18753-18762(2006).
Roach W.,et al.Biochem. Biophys. Res. Commun. 355:745-750(2007).
Villen J.,et al.Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
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