|Other Accession||NM_001008224, NP_001008225|
|Reactivity||Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Alias Symbol||FLJ10128, KIAA1561, MGC141967, MGC141969, NUCLING|
|Other Names||Uveal autoantigen with coiled-coil domains and ankyrin repeats, UACA, KIAA1561|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-UACA antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||UACA antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1 (By similarity).|
|Cellular Location||Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Expressed diffusely in cytoplasm|
|Tissue Location||Highly expressed in skeletal muscle, heart, kidney and pancreas. Expressed in choroid, retina and epidermal melanocytes Expressed in eye muscles and thyroid follicular cells|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Yamada K.,et al.Biochem. Biophys. Res. Commun. 280:1169-1176(2001).
Nagase T.,et al.DNA Res. 7:273-281(2000).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
Zody M.C.,et al.Nature 440:671-675(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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