|Other Accession||NM_013252, NP_037384|
|Reactivity||Human, Rat, Pig, Horse, Yeast, Bovine, Dog|
|Alias Symbol||CLECSF5, MDL-1, MDL1, MGC138304|
|Other Names||C-type lectin domain family 5 member A, C-type lectin superfamily member 5, Myeloid DAP12-associating lectin 1, MDL-1, CLEC5A, CLECSF5, MDL1|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-CLEC5A antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||CLEC5A antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a positive regulator of osteoclastogenesis (By similarity). Cell surface receptor that signals via TYROBP (PubMed:10449773). Regulates inflammatory responses (By similarity).|
|Cellular Location||Cell membrane; Single-pass type II membrane protein|
|Tissue Location||Highly expressed in bone marrow with lower levels in synovium, lung and bronchus (PubMed:20212065). Expressed in peripheral blood monocytes and in the monocyte/macrophage cell lines U- 937 and Mono-Mac-6, but not in cell lines of other origins (PubMed:10449773). Expression is down-regulated when monocytes differentiate into dendritic cells (PubMed:10449773)|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Bakker A.B.H.,et al.Proc. Natl. Acad. Sci. U.S.A. 96:9792-9796(1999).
Mueller A.,et al.Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
Hillier L.W.,et al.Nature 424:157-164(2003).
Chen S.T.,et al.Nature 453:672-676(2008).
Watson A.A.,et al.J. Biol. Chem. 286:24208-24218(2011).
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