DHRS4 antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q9BTZ2 |
Other Accession | NM_021004, NP_066284 |
Reactivity | Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog |
Predicted | Human, Mouse, Rat, Rabbit, Pig, Bovine, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 29kDa |
Gene ID | 10901 |
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Alias Symbol | FLJ11008, NRDR, SCAD-SRL, SDR-SRL, SDR25C1 |
Other Names | Dehydrogenase/reductase SDR family member 4, 1.1.1.184, NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase, CR, PHCR, NADPH-dependent retinol dehydrogenase/reductase, NRDR, humNRDR, Peroxisomal short-chain alcohol dehydrogenase, PSCD, SCAD-SRL, Short-chain dehydrogenase/reductase family member 4, DHRS4 |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-DHRS4 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | DHRS4 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | DHRS4 (HGNC:16985) |
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Function | NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including ketosteroids, alpha-dicarbonyl compounds, aldehydes, aromatic ketones and quinones (PubMed:18571493, PubMed:19056333). Reduces 3-ketosteroids and benzil into 3beta-hydroxysteroids and R-benzoin, respectively, in contrast to the stereoselectivity of non-primate DHRS4s which produce 3alpha-hydroxysteroids and S-benzoin (PubMed:19056333). Diplays low activity toward all-trans-retinal and no activity toward 9-cis-retinal as compared to non-primate mammals (PubMed:18571493, PubMed:19056333). In the reverse reaction, catalyze the NAD-dependent oxidation of 3beta- hydroxysteroids and alcohol, but with much lower efficiency (PubMed:18571493, PubMed:19056333). Involved in the metabolism of 3beta-hydroxysteroids, isatin and xenobiotic carbonyl compounds (PubMed:18571493, PubMed:19056333). |
Cellular Location | [Isoform 1]: Peroxisome Note=Isoform 4 is not peroxisomal. |
Tissue Location | [Isoform 1]: Predominantly expressed in normal cervix (at protein level). [Isoform 5]: Expressed in a few neoplastic cervical tissues. [Isoform 8]: High expression in liver. |
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Provided below are standard protocols that you may find useful for product applications.
References
Fransen M.,et al.Biochem. J. 340:561-568(1999).
Furukawa A.,et al.Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
Du J.,et al.Yi Chuan Xue Bao 31:661-667(2004).
Tu Q.,et al.Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
Li Y.F.,et al.Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
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