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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   GADD45GIP1 antibody - middle region   

GADD45GIP1 antibody - middle region

Rabbit Polyclonal Antibody

  • WB - GADD45GIP1 antibody - middle region AI14810

    WB Suggested Anti-GADD45GIP1 Antibody Titration: 1.0 μg/ml
    Positive Control: Hela Whole CellGADD45GIP1 is supported by BioGPS gene expression data to be expressed in HeLa
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8TAE8
Other Accession NM_052850, NP_443082
Reactivity Human, Mouse, Rat, Rabbit, Pig, Horse, Yeast, Bovine, Guinea Pig, Dog
Predicted Human, Rabbit, Guinea Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 24kDa
Additional Information
Gene ID 90480
Alias Symbol CKBBP2, CRIF1, MGC4667, MGC4758, PLINP-1, PRG6, Plinp1
Other Names Growth arrest and DNA damage-inducible proteins-interacting protein 1, 39S ribosomal protein L59, mitochondrial, MRP-L59, CKII beta-associating protein, CR6-interacting factor 1, CRIF1, Papillomavirus L2-interacting nuclear protein 1, PLINP, PLINP-1, p53-responsive gene 6 protein, GADD45GIP1, MRPL59, PLINP1, PRG6
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-GADD45GIP1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsGADD45GIP1 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms MRPL59, PLINP1, PRG6
Function Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.
Cellular Location Mitochondrion. Nucleus Note=Using N-terminally tagged constructs, has been found in the nucleus (PubMed:12482659). C-terminally tagged constructs are targeted exclusively to mitochondria (PubMed:22453275). This discrepancy may be explained by masking of a potential N-terminal mitochondrial targeting signal by the tag (PubMed:22453275).
Tissue Location Widely expressed. Highly expressed in the thyroid gland, heart, lymph nodes, trachea and adrenal tissues. Expressed at lower level in liver skeletal muscle, kidney, pancreas, testis, ovary and stomach. Barely detectable in adrenal adenoma and papillary thyroid cancer.
Research Areas
Citations (0)

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Goernemann J.,et al.Virology 303:69-78(2002).
Chung H.K.,et al.J. Biol. Chem. 278:28079-28088(2003).
Frigimelica E.,et al.Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
Horikoshi N.,et al.Biochem. Biophys. Res. Commun. 261:864-869(1999).
Park K.C.,et al.Mol. Endocrinol. 19:12-24(2005).

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$ 389.00
Cat# AI14810
Availability: 2-3 days
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