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GPR37L1 antibody - C-terminal region

Rabbit Polyclonal Antibody

  • WB - GPR37L1 antibody - C-terminal region AI14837

    WB Suggested Anti-GPR37L1 Antibody Titration: 1.0 μg/ml
    Positive Control: Fetal Brain
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O60883
Other Accession NM_004767, NP_004758
Reactivity Human, Mouse, Rat, Pig, Horse, Dog
Predicted Human, Mouse, Rat, Horse, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 53kDa
Additional Information
Gene ID 9283
Alias Symbol ET(B)R-LP-2, ETBR-LP-2
Other Names Prosaposin receptor GPR37L1, Endothelin B receptor-like protein 2, ETBR-LP-2, G-protein coupled receptor 37-like 1, GPR37L1, ETBRLP2
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-GPR37L1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsGPR37L1 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GPR37L1
Synonyms ETBRLP2
Function G-protein coupled receptor (PubMed:27072655). Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (PubMed:23690594). However, other studies have shown that prosaposin does not increase activity (PubMed:27072655, PubMed:28688853). It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha (PubMed:27072655). Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway (By similarity). Regulates baseline blood pressure in females and protects against cardiovascular stress in males (By similarity). Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity (By similarity).
Cellular Location Cell membrane; Multi-pass membrane protein. Cell projection, cilium membrane {ECO:0000250|UniProtKB:Q99JG2}; Multi-pass membrane protein. Note=Associates with the basal membrane of Bergmann glia cell primary cilia. {ECO:0000250|UniProtKB:Q99JG2}
Tissue Location Expressed in primary cortical astrocytes (at protein level) (PubMed:23690594). Expressed in the central nervous system (PubMed:9539149).
Research Areas
Citations (0)

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Valdenaire O.,et al.FEBS Lett. 424:193-196(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Gregory S.G.,et al.Nature 441:315-321(2006).
Halim A.,et al.J. Proteome Res. 12:573-584(2013).

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$ 389.00
Cat# AI14837
Availability: 2-3 days
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