|Other Accession||NM_003094, NP_003085|
|Reactivity||Human, Mouse, Rat, Bovine, Guinea Pig, Dog|
|Predicted||Mouse, Rat, Dog|
|Alias Symbol||B-raf, SME, Sm-E|
|Other Names||Small nuclear ribonucleoprotein E, snRNP-E, Sm protein E, Sm-E, SmE, SNRPE|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-SNRPE antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||SNRPE antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:23246290, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346). Is also a component of the minor U12 spliceosome (PubMed:15146077). As part of the U7 snRNP it is involved in histone 3'-end processing (PubMed:12975319). May indirectly play a role in hair development (PubMed:23246290).|
|Cellular Location||Cytoplasm, cytosol. Nucleus. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.|
|Tissue Location||Widely expressed. In scalp skin, it is present in the hair follicle, the epidermis, and the dermis|
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Provided below are standard protocols that you may find useful for product applications.
Stanford D.R.,et al.Nucleic Acids Res. 16:10593-10605(1988).
Stanford D.R.,et al.J. Biol. Chem. 263:17772-17779(1988).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Stanford D.R.,et al.J. Biol. Chem. 262:9931-9934(1987).
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