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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   CFI antibody - N-terminal region   

CFI antibody - N-terminal region

Rabbit Polyclonal Antibody

     
  • WB - CFI antibody - N-terminal region AI14937

    WB Suggested Anti-CFI Antibody Titration: 1.0 μg/ml
    Positive Control: Hela Whole Cell
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P05156
Other Accession NM_000204, NP_000195
Reactivity Human
Predicted Human
Host Rabbit
Clonality Polyclonal
Calculated MW 64kDa
Additional Information
Gene ID 3426
Alias Symbol AHUS3, C3BINA, C3b-INA, FI, IF, KAF
Other Names Complement factor I, 3.4.21.45, C3B/C4B inactivator, Complement factor I heavy chain, Complement factor I light chain, CFI, IF
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-CFI antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsCFI antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CFI
Synonyms IF
Function Trypsin-like serine protease that plays an essential role in regulating the immune response by controlling all complement pathways. Inhibits these pathways by cleaving three peptide bonds in the alpha- chain of C3b and two bonds in the alpha-chain of C4b thereby inactivating these proteins (PubMed:7360115, PubMed:17320177). Essential cofactors for these reactions include factor H and C4BP in the fluid phase and membrane cofactor protein/CD46 and CR1 on cell surfaces (PubMed:2141838, PubMed:9605165, PubMed:12055245). The presence of these cofactors on healthy cells allows degradation of deposited C3b by CFI in order to prevent undesired complement activation, while in apoptotic cells or microbes, the absence of such cofactors leads to C3b-mediated complement activation and subsequent opsonization (PubMed:28671664).
Cellular Location Secreted, extracellular space. Secreted
Tissue Location Expressed in the liver by hepatocytes (PubMed:6327681). Also present in other cells such as monocytes, fibroblasts or keratinocytes (PubMed:6444659, PubMed:17320177)
Research Areas
Citations (0)

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References

Catterall C.F.,et al.Biochem. J. 242:849-856(1987).
Goldberger G.,et al.J. Biol. Chem. 262:10065-10071(1987).
Hillier L.W.,et al.Nature 434:724-731(2005).
Minta J.O.,et al.Gene 208:17-24(1998).
Ullman C.G.,et al.FEBS Lett. 371:199-203(1995).

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$ 389.00
Cat# AI14937
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