|Other Accession||NM_009231, NP_033257|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Alias Symbol||4430401P03Rik, 9630010N06, AI449023|
|Other Names||Son of sevenless homolog 1, SOS-1, mSOS-1, Sos1|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Sos1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Sos1 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Promotes the exchange of Ras-bound GDP by GTP. Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3 in response to EGF (By similarity). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (PubMed:10499589, PubMed:11524436).|
|Tissue Location||Expressed in most embryonic and adult tissues.|
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Provided below are standard protocols that you may find useful for product applications.
Bowtell D.D.,et al.Proc. Natl. Acad. Sci. U.S.A. 89:6511-6515(1992).
Scita G.,et al.Nature 401:290-293(1999).
Scita G.,et al.J. Cell Biol. 154:1031-1044(2001).
Munton R.P.,et al.Mol. Cell. Proteomics 6:283-293(2007).
Villen J.,et al.Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
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