|Other Accession||NM_015717, NP_056532|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig|
|Predicted||Mouse, Rat, Pig, Horse, Bovine, Guinea Pig|
|Other Names||C-type lectin domain family 4 member K, Langerin, CD207, CD207, CLEC4K|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-CD207 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||CD207 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.|
|Cellular Location||Membrane; Single- pass type II membrane protein. Note=Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes|
|Tissue Location||Exclusively expressed by Langerhans cells. Expressed in astrocytoma and malignant ependymoma, but not in normal brain tissues.|
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Provided below are standard protocols that you may find useful for product applications.
Valladeau J.,et al.Immunity 12:71-81(2000).
Hillier L.W.,et al.Nature 434:724-731(2005).
Stambach N.S.,et al.Glycobiology 13:401-410(2003).
Valladeau J.,et al.Immunol. Res. 28:93-107(2003).
de Witte L.,et al.Nat. Med. 13:367-371(2007).
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