NOXO1 antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q8NFA2 |
Other Accession | NM_172168, NP_751908 |
Reactivity | Human, Horse, Bovine |
Predicted | Human, Horse, Bovine |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 41kDa |
Gene ID | 124056 |
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Alias Symbol | MGC20258, P41NOX, P41NOXA, P41NOXB, P41NOXC, SH3PXD5, SNX28 |
Other Names | NADPH oxidase organizer 1, NADPH oxidase regulatory protein, Nox organizer 1, Nox-organizing protein 1, SH3 and PX domain-containing protein 5, NOXO1, P41NOX, SH3PXD5 |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-NOXO1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | NOXO1 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | NOXO1 |
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Synonyms | P41NOX, SH3PXD5 |
Function | Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity. |
Cellular Location | [Isoform 3]: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Isoform 3 associates with the plasma membrane in a lipid-dependent manner (PubMed:12716910) |
Tissue Location | Expressed in testis, small and large intestines, liver, kidney and pancreas. Isoform 3 is mainly expressed in colon Isoform 1 is preferentially expressed in testis |
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Provided below are standard protocols that you may find useful for product applications.
References
Banfi B.,et al.J. Biol. Chem. 278:3510-3513(2003).
Geiszt M.,et al.J. Biol. Chem. 278:20006-20012(2003).
Takeya R.,et al.J. Biol. Chem. 278:25234-25246(2003).
Cheng G.,et al.J. Biol. Chem. 279:4737-4742(2004).
Cheng G.,et al.Gene 356:118-126(2005).
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