|Other Accession||NM_031430, NP_113618|
|Alias Symbol||FLJ31193, PP10141|
|Other Names||Rab-interacting lysosomal protein, RILP|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-RILP antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||RILP antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Rab effector playing a role in late endocytic transport to degradative compartments (PubMed:11696325, PubMed:14668488, PubMed:27113757, PubMed:11179213, PubMed:12944476). Involved in the regulation of lysosomal morphology and distribution (PubMed:14668488, PubMed:27113757). Induces recruitment of dynein-dynactin motor complexes to Rab7A-containing late endosome and lysosome compartments (PubMed:11179213, PubMed:11696325). Promotes centripetal migration of phagosomes and the fusion of phagosomes with the late endosomes and lysosomes (PubMed:12944476).|
|Cellular Location||Late endosome membrane. Lysosome membrane. Cytoplasmic vesicle, phagosome membrane. Note=Associated with late endosomal, lysosomal and phagosomal membranes. The interaction with RAB7A is necessary for its recruitment to phagosomes|
|Tissue Location||Ubiquitous. Strongly expressed in fetal heart, heart, stomach, spleen, adrenal gland, thyroid gland, salivary gland, fetal liver, liver and lung. Poorly expressed in brain|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Cantalupo G.,et al.EMBO J. 20:683-693(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Wan D.,et al.Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).
Frigimelica E.,et al.Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
Bucci C.,et al.Biochem. Biophys. Res. Commun. 286:815-819(2001).
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