|Application ||WB, IF|
|Other Accession||NM_002203, NP_002194|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Alias Symbol||BR, CD49B, GPIa, VLA-2, VLAA2, BDPLT9|
|Other Names||Integrin alpha-2, CD49 antigen-like family member B, Collagen receptor, Platelet membrane glycoprotein Ia, GPIa, VLA-2 subunit alpha, CD49b, ITGA2, CD49B|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-ITGA2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||ITGA2 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human echoviruses 1 and 8.|
|Cellular Location||Membrane; Single-pass type I membrane protein.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Takada Y.,et al.J. Cell Biol. 109:397-407(1989).
Schmutz J.,et al.Nature 431:268-274(2004).
Zutter M.M.,et al.J. Biol. Chem. 269:463-469(1994).
Bergelson J.M.,et al.J. Virol. 67:6847-6852(1993).
Graham K.L.,et al.J. Virol. 77:9969-9978(2003).
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