|Other Accession||NM_006406, NP_006397|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Alias Symbol||AOE37-2, PRX-4|
|Other Names||Peroxiredoxin-4, 18.104.22.168, Antioxidant enzyme AOE372, AOE37-2, Peroxiredoxin IV, Prx-IV, Thioredoxin peroxidase AO372, Thioredoxin-dependent peroxide reductase A0372, PRDX4|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-PRDX4 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||PRDX4 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation.|
|Cellular Location||Cytoplasm. Endoplasmic reticulum. Note=Cotranslationally translocated to and retained within the endoplasmic reticulum. A small fraction of the protein is cytoplasmic.|
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Provided below are standard protocols that you may find useful for product applications.
Jin D.-Y.,et al.J. Biol. Chem. 272:30952-30961(1997).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Xu G.,et al.Proc. Natl. Acad. Sci. U.S.A. 106:19310-19315(2009).
Lubec G.,et al.Submitted (DEC-2008) to UniProtKB.
Wagner E.,et al.Biochem. J. 366:777-785(2002).
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