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RFK Antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q969G6 |
| Other Accession | NM_018339, NP_060809 |
| Reactivity | Human, Mouse, Rat, Rabbit, Pig, Horse, Yeast, Bovine, Guinea Pig, Dog |
| Predicted | Human, Mouse, Rat, Rabbit, Pig, Horse, Yeast, Bovine, Guinea Pig, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 17kDa |
| Gene ID | 55312 |
|---|---|
| Alias Symbol | FLJ11149, RIFK, RP11-422N19.2 |
| Other Names | Riboflavin kinase, 2.7.1.26, ATP:riboflavin 5'-phosphotransferase, Flavokinase, RFK |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-RFK antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | RFK Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RFK |
|---|---|
| Function | Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF- activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase. |
| Cellular Location | Cytoplasm. |
| Tissue Location | Detected in brain, placenta and urinary bladder. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Humphray S.J.,et al.Nature 429:369-374(2004).
Yazdanpanah B.,et al.Nature 460:1159-1163(2009).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).
Karthikeyan S.,et al.Structure 11:265-273(2003).
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