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GNA11 antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P43444 |
| Other Accession | NM_002067, NP_002058 |
| Reactivity | Human, Mouse, Rat, Rabbit, Pig, Goat, Sheep, Horse, Guinea Pig, Dog |
| Predicted | Human, Mouse, Rat, Rabbit, Pig, Goat, Sheep, Horse, Guinea Pig, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 41kDa |
| Gene ID | 779103 |
|---|---|
| Alias Symbol | GNA-11 |
| Other Names | Guanine nucleotide-binding protein subunit alpha-11, G alpha-11, G-protein subunit alpha-11, gna11 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-GNA11 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | GNA11 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | gna11 |
|---|---|
| Function | Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. Signaling is mediated via phospholipase C-beta- dependent inositol lipid hydrolysis for signal propagation: activates phospholipase C-beta: following GPCR activation, GNA11 activates PLC- beta (PLCB1, PLCB2, PLCB3 or PLCB4), leading to production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:P29992}; Lipid-anchor {ECO:0000250|UniProtKB:P29992}. Cytoplasm {ECO:0000250|UniProtKB:P29992} |
Citations (0)
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
Submit your citation using an Abcepta antibody to
info@abcepta.com, and receive a free "I Love Antibodies" mug.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Shapira H.,et al.FEBS Lett. 348:89-92(1994).
Shapira H.,et al.FEBS Lett. 349:318-318(1994).
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$ 389.00
Cat# AI15176
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