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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   NLRP12 Antibody - N-terminal region   

NLRP12 Antibody - N-terminal region

Rabbit Polyclonal Antibody

     
  • WB - NLRP12 Antibody - N-terminal region AI15179

    Host: Rabbit
    Target Name: NLRP12
    Sample Tissue: Hela Whole cell lysate
    s
    Antibody Dilution: 1.0μg/ml
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P59046
Other Accession NP_653288
Reactivity Human
Predicted Human, Rat, Pig, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 116kDa
Additional Information
Gene ID 91662
Alias Symbol NLRP12, NALP12, PYPAF7, RNO,
Other Names NACHT, LRR and PYD domains-containing protein 12, Monarch-1, PYRIN-containing APAF1-like protein 7, Regulated by nitric oxide, NLRP12, NALP12, PYPAF7, RNO
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 &mu, l of distilled water. Final Anti-NLRP12 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
PrecautionsNLRP12 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NLRP12
Synonyms NALP12, PYPAF7, RNO
Function Plays an essential role as an potent mitigator of inflammation (PubMed:30559449). Primarily expressed in dendritic cells and macrophages, inhibits both canonical and non-canonical NF-kappa-B and ERK activation pathways (PubMed:15489334, PubMed:17947705). Functions as a negative regulator of NOD2 by targeting it to degradation via the proteasome pathway (PubMed:30559449). In turn, promotes bacterial tolerance (PubMed:30559449). Inhibits also the DDX58-mediated immune signaling against RNA viruses by reducing the E3 ubiquitin ligase TRIM25-mediated 'Lys-63'-linked DDX58 activation but enhancing the E3 ubiquitin ligase RNF125-mediated 'Lys-48'-linked DDX58 degradation (PubMed:30902577). Acts also as a negative regulator of inflammatory response to mitigate obesity and obesity-associated diseases in adipose tissue (By similarity).
Cellular Location Cytoplasm.
Tissue Location Detected only in peripheral blood leukocytes, predominantly in eosinophils and granulocytes, and at lower levels in monocytes.
Research Areas
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References

Wang L.,et al.J. Biol. Chem. 277:29874-29880(2002).
Tschopp J.,et al.Nat. Rev. Mol. Cell Biol. 4:95-104(2003).
Williams K.L.,et al.Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
Shami P.J.,et al.Br. J. Haematol. 112:138-147(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 389.00
Cat# AI15179
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