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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   SEC61A1 Antibody - C-terminal region   

SEC61A1 Antibody - C-terminal region

Rabbit Polyclonal Antibody

  • WB - SEC61A1 Antibody - C-terminal region AI15206

    WB Suggested Anti-SEC61A1 Antibody Titration: 1.0 μg/ml
    Positive Control: HT1080 Whole CellSEC61A1 is supported by BioGPS gene expression data to be expressed in HT1080
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P61619
Other Accession NM_013336, NP_037468
Reactivity Human, Mouse, Rat, Rabbit, Pig, Goat, Horse, Bovine, Guinea Pig, Dog
Predicted Human, Mouse, Rat, Rabbit, Pig, Goat, Horse, Bovine, Guinea Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 52kDa
Additional Information
Gene ID 29927
Alias Symbol HSEC61, SEC61, SEC61A
Other Names Protein transport protein Sec61 subunit alpha isoform 1, Sec61 alpha-1, SEC61A1, SEC61A
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-SEC61A1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsSEC61A1 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SEC61A1
Synonyms SEC61A
Function Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER) (PubMed:12475939, PubMed:22375059, PubMed:28782633, PubMed:29719251, PubMed:32814900). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (PubMed:22375059, PubMed:28782633, PubMed:29719251). May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post- translational transport of small presecretory proteins (PubMed:22375059, PubMed:29719251). Controls the passive efflux of calcium ions from the ER lumen to the cytosol through SEC61 channel, contributing to the maintenance of cellular calcium homeostasis (PubMed:28782633). Component of a ribosome-associated ER translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis (PubMed:32820719). Together with SEC61 and TMCO1, forms the lipid-filled cavity at the center of the translocon where TMEM147 may insert hydrophobic segments of mutli-pass membrane proteins from the lumen into de central membrane cavity in a process gated by SEC61, and TMCO1 may insert hydrophobic segments of nascent chains from the cytosol into the cavity (PubMed:32820719). Plays a critical role in nephrogenesis, specifically at pronephros stage (By similarity).
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Localizes exclusively in granular structures in the endoplasmic reticulum (ER).
Tissue Location Expressed in proximal and distal tubules in kidney (at protein level).
Research Areas
Citations (0)

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Liu T.,et al.Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.
Li W.,et al.Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
Finke K.,et al.Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).

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$ 389.00
Cat# AI15206
Availability: 2-3 days
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