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>   home   >   Products   >   Primary Antibodies   >   APLF Antibody - C-terminal region   

APLF Antibody - C-terminal region

Rabbit Polyclonal Antibody

  • WB - APLF Antibody - C-terminal region AI15209

    WB Suggested Anti-APLF Antibody Titration: 1.0 μg/ml
    Positive Control: PANC1 Whole Cell
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8IW19
Other Accession NM_173545, NP_775816
Reactivity Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine
Predicted Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 57kDa
Additional Information
Gene ID 200558
Alias Symbol APFL, C2orf13, FLJ16593, MGC47799, PALF, Xip1
Other Names Aprataxin and PNK-like factor,, Apurinic-apyrimidinic endonuclease APLF, PNK and APTX-like FHA domain-containing protein, XRCC1-interacting protein 1, APLF, C2orf13, PALF, XIP1
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-APLF antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsAPLF Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms C2orf13, PALF, XIP1
Function Nuclease involved in single-strand and double-strand DNA break repair (PubMed:17353262, PubMed:17396150). Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post- translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions (PubMed:17353262, PubMed:17396150, PubMed:21211721). Displays apurinic- apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage (PubMed:17353262, PubMed:17396150). Together with PARP3, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ) (PubMed:21211721).
Cellular Location Nucleus. Chromosome. Cytoplasm, cytosol. Note=Localizes to DNA damage sites (PubMed:18474613, PubMed:18172500, PubMed:21211721). Accumulates at single-strand breaks and double-strand breaks via the PBZ-type zinc fingers (PubMed:18172500).
Citations (0)

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Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
Kanno S.,et al.EMBO J. 26:2094-2103(2007).
Bekker-Jensen S.,et al.J. Biol. Chem. 282:19638-19643(2007).
Iles N.,et al.Mol. Cell. Biol. 27:3793-3803(2007).

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$ 389.00
Cat# AI15209
Availability: 2-3 days
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