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PHOSPHO1 antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q8TCT1 |
| Other Accession | NM_001143804, NP_001137276 |
| Reactivity | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Dog |
| Predicted | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 32kDa |
| Gene ID | 162466 |
|---|---|
| Other Names | Phosphoethanolamine/phosphocholine phosphatase, 3.1.3.75, PHOSPHO1 |
| Target/Specificity | This antibody is 100% homologous to both isoforms of human PHOSPHO1. |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-PHOSPHO1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | PHOSPHO1 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PHOSPHO1 {ECO:0000303|PubMed:12464021, ECO:0000312|HGNC:HGNC:16815} |
|---|---|
| Function | Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho) (PubMed:15175005). Involved in the generation of inorganic phosphate for bone mineralization (By similarity). Acts in a non-redundant manner with PHOSPHO1 in skeletal mineralization: while PHOSPHO1 mediates the initiation of hydroxyapatite crystallization in the matrix vesicles (MVs), ALPL/TNAP catalyzes the spread of hydroxyapatite crystallization in the extracellular matrix (By similarity). |
| Cellular Location | Extracellular vesicle {ECO:0000250|UniProtKB:Q8R2H9}. Note=Localizes to special class of extracellular vesicles, named matrix vesicles (MVs), which are released by osteogenic cells. {ECO:0000250|UniProtKB:Q8R2H9} |
| Tissue Location | Expressed at sites of mineralization in bone and cartilage. Highly expressed in osteoblast cell line SaOS-2 which produces a mineralized matrix, but not in MG-63 cell line, which do not mineralize. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
References
Houston B.,et al.Anim. Genet. 33:451-454(2002).
Roberts S.J.,et al.Biochem. Biophys. Res. Commun. 371:872-876(2008).
Zody M.C.,et al.Nature 440:1045-1049(2006).
Roberts S.J.,et al.Biochem. J. 382:59-65(2004).
Houston B.,et al.Bone 34:629-637(2004).
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