|Other Accession||NM_025009, NP_079285|
|Reactivity||Human, Rabbit, Pig, Horse, Bovine, Dog|
|Predicted||Human, Rabbit, Pig, Horse, Bovine, Dog|
|Alias Symbol||CEP4, KIAA0635|
|Other Names||Centrosomal protein of 135 kDa, Cep135, Centrosomal protein 4, CEP135, CEP4, KIAA0635|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-CEP135 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||CEP135 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865).|
|Cellular Location||Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=During centriole biogenesis, it is concentrated within the proximal lumen of both parental centrioles and procentrioles|
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Provided below are standard protocols that you may find useful for product applications.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
Ishikawa K.,et al.DNA Res. 5:169-176(1998).
Andersen J.S.,et al.Nature 426:570-574(2003).
Kleylein-Sohn J.,et al.Dev. Cell 13:190-202(2007).
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