|Other Accession||NM_001134693, NP_001128165|
|Reactivity||Human, Mouse, Rat, Dog|
|Predicted||Human, Mouse, Rat, Dog|
|Other Names||Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4, OST4|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-OST4 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||OST4 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. Specifically involved in maintaining stability of STT3A-containing OST complexes.|
|Cellular Location||Endoplasmic reticulum. Endoplasmic reticulum membrane; Single- pass type III membrane protein. Note=The single transmembrane helix has a kink in the middle of the transmembrane span|
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Provided below are standard protocols that you may find useful for product applications.
Hillier L.W.,et al.Nature 434:724-731(2005).
Gayen S.,et al.Biochem. Biophys. Res. Commun. 409:572-576(2011).
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