|Other Accession||NM_005720, NP_005711|
|Reactivity||Human, Mouse, Rat, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Pig, Bovine, Guinea Pig, Dog|
|Alias Symbol||ARC41, p40-ARC, p41-ARC|
|Other Names||Actin-related protein 2/3 complex subunit 1B, Arp2/3 complex 41 kDa subunit, p41-ARC, ARPC1B, ARC41|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-ARPC1B antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||ARPC1B Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:11741539, PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:11741539, PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double- strand breaks (DSBs) (PubMed:29925947).|
|Cellular Location||Cytoplasm, cytoskeleton. Nucleus|
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Provided below are standard protocols that you may find useful for product applications.
Welch M.D.,et al.J. Cell Biol. 138:375-384(1997).
Hillier L.W.,et al.Nature 424:157-164(2003).
Gevaert K.,et al.Nat. Biotechnol. 21:566-569(2003).
Gournier H.,et al.Mol. Cell 8:1041-1052(2001).
Olsen J.V.,et al.Cell 127:635-648(2006).
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