HABP4 Antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application ![]()
| WB |
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Primary Accession | Q5JVS0 |
Other Accession | NM_014282, NP_055097 |
Reactivity | Human, Mouse, Rat, Bovine |
Predicted | Human, Mouse, Rat, Bovine |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 46kDa |
Gene ID | 22927 |
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Alias Symbol | IHABP4, Ki-1/57, MGC825, SERBP1L |
Other Names | Intracellular hyaluronan-binding protein 4, IHABP-4, IHABP4, Ki-1/57 intracellular antigen, HABP4 (HGNC:17062) |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-HABP4 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | HABP4 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | HABP4 (HGNC:17062) |
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Function | RNA-binding protein that plays a role in the regulation of transcription, pre-mRNA splicing and mRNA translation (PubMed:14699138, PubMed:16455055, PubMed:19523114, PubMed:21771594). Negatively regulates DNA-binding activity of the transcription factor MEF2C in myocardial cells in response to mechanical stress (By similarity). Plays a role in pre-mRNA splicing regulation (PubMed:19523114). Binds (via C-terminus) to poly(U) RNA (PubMed:19523114). Involved in mRNA translation regulation, probably at the initiation step (PubMed:21771594). Seems to play a role in PML-nuclear bodies formation (PubMed:28695742). |
Cellular Location | Nucleus. Cytoplasm. Cytoplasm, Stress granule. Cytoplasm, sarcoplasm {ECO:0000250|UniProtKB:A1L1K8}. Nucleus, nuclear body. Nucleus, nucleolus. Nucleus speckle. Nucleus, Cajal body. Nucleus, gem. Note=Transported into the nuclear compartment in activated leukocytes (PubMed:9523163). Inhibition of methylation alters its distribution between the nuclear and cytoplasmic compartments (PubMed:16879614, PubMed:19523114). Methylation may be required for its localization in subnuclear structures, such as nucleoli, nuclear speckles, Cajal bodies and Gemini of coiled bodies (gems) (PubMed:19523114). Colocalizes with FMR1, FXR1 and FXR2 in cytoplasmic stress granules (PubMed:21771594). In myocardial cells, localization at the sarcoplasm is reduced in response to mechanical stress (By similarity). {ECO:0000250|UniProtKB:A1L1K8, ECO:0000269|PubMed:16879614, ECO:0000269|PubMed:19523114, ECO:0000269|PubMed:21771594, ECO:0000269|PubMed:9523163} |
Tissue Location | Highly expressed in brain, heart, and kidney, and moderately expressed in skeletal muscle. Also expressed in a variety of tumor cell lines and in activated but not resting leukocytes |

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Provided below are standard protocols that you may find useful for product applications.
References
Huang L.,et al.J. Biol. Chem. 275:29829-29839(2000).
Humphray S.J.,et al.Nature 429:369-374(2004).
Kobarg J.,et al.Exp. Clin. Immunogenet. 14:273-280(1997).
Lemos T.A.,et al.FEBS Lett. 533:14-20(2003).
Nery F.C.,et al.J. Biol. Chem. 279:11444-11455(2004).

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