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>   home   >   Products   >   Primary Antibodies   >   HABP4 Antibody - N-terminal region   

HABP4 Antibody - N-terminal region

Rabbit Polyclonal Antibody

     
  • WB - HABP4 Antibody - N-terminal region AI15334

    WB Suggested Anti-HABP4 Antibody Titration: 1.0 μg/ml
    Positive Control: 721_B Whole Cell
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q5JVS0
Other Accession NM_014282, NP_055097
Reactivity Human, Mouse, Rat, Bovine
Predicted Human, Mouse, Rat, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 46kDa
Additional Information
Gene ID 22927
Alias Symbol IHABP4, Ki-1/57, MGC825, SERBP1L
Other Names Intracellular hyaluronan-binding protein 4, IHABP-4, IHABP4, Ki-1/57 intracellular antigen, HABP4 (HGNC:17062)
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-HABP4 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsHABP4 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HABP4 (HGNC:17062)
Function RNA-binding protein that plays a role in the regulation of transcription, pre-mRNA splicing and mRNA translation (PubMed:14699138, PubMed:16455055, PubMed:19523114, PubMed:21771594). Negatively regulates DNA-binding activity of the transcription factor MEF2C in myocardial cells in response to mechanical stress (By similarity). Plays a role in pre-mRNA splicing regulation (PubMed:19523114). Binds (via C-terminus) to poly(U) RNA (PubMed:19523114). Involved in mRNA translation regulation, probably at the initiation step (PubMed:21771594). Seems to play a role in PML-nuclear bodies formation (PubMed:28695742).
Cellular Location Nucleus. Cytoplasm. Cytoplasm, Stress granule. Cytoplasm, sarcoplasm {ECO:0000250|UniProtKB:A1L1K8}. Nucleus, nuclear body. Nucleus, nucleolus. Nucleus speckle. Nucleus, Cajal body. Nucleus, gem. Note=Transported into the nuclear compartment in activated leukocytes (PubMed:9523163). Inhibition of methylation alters its distribution between the nuclear and cytoplasmic compartments (PubMed:16879614, PubMed:19523114). Methylation may be required for its localization in subnuclear structures, such as nucleoli, nuclear speckles, Cajal bodies and Gemini of coiled bodies (gems) (PubMed:19523114). Colocalizes with FMR1, FXR1 and FXR2 in cytoplasmic stress granules (PubMed:21771594). In myocardial cells, localization at the sarcoplasm is reduced in response to mechanical stress (By similarity). {ECO:0000250|UniProtKB:A1L1K8, ECO:0000269|PubMed:16879614, ECO:0000269|PubMed:19523114, ECO:0000269|PubMed:21771594, ECO:0000269|PubMed:9523163}
Tissue Location Highly expressed in brain, heart, and kidney, and moderately expressed in skeletal muscle. Also expressed in a variety of tumor cell lines and in activated but not resting leukocytes
Citations (0)

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References

Huang L.,et al.J. Biol. Chem. 275:29829-29839(2000).
Humphray S.J.,et al.Nature 429:369-374(2004).
Kobarg J.,et al.Exp. Clin. Immunogenet. 14:273-280(1997).
Lemos T.A.,et al.FEBS Lett. 533:14-20(2003).
Nery F.C.,et al.J. Biol. Chem. 279:11444-11455(2004).

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$ 389.00
Cat# AI15334
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