|Other Accession||NM_052891, NP_443123|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Alias Symbol||MGC149197, PGRP-Ialpha, PGRPIA|
|Other Names||Peptidoglycan recognition protein 3, Peptidoglycan recognition protein I-alpha, PGLYRPIalpha, PGRP-I-alpha, Peptidoglycan recognition protein intermediate alpha, PGLYRP3, PGRPIA|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-PGLYRP3 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||PGLYRP3 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity.|
|Tissue Location||Detected in skin epidermis, eccrine sweat glands and ducts, ciliary body epithelial cells of the eye, in small intestine, colon, stomach and in mature epithelial cells of the tongue (at protein level). Highly expressed in skin and esophagus, expressed also in tonsils and thymus and to a much lesser extent in the stomach, descending colon, rectum and brain.|
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Provided below are standard protocols that you may find useful for product applications.
Liu C.,et al.J. Biol. Chem. 276:34686-34694(2001).
Gregory S.G.,et al.Nature 441:315-321(2006).
Lu X.,et al.J. Biol. Chem. 281:5895-5907(2006).
Guan R.,et al.J. Biol. Chem. 279:31873-31882(2004).
Guan R.,et al.Proc. Natl. Acad. Sci. U.S.A. 101:17168-17173(2004).
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