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RAB30 Antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q15771 |
| Other Accession | NM_014488, NP_055303 |
| Reactivity | Human, Mouse, Rat, Rabbit, Goat, Horse, Bovine, Guinea Pig, Dog |
| Predicted | Human, Mouse, Rat, Rabbit, Pig, Goat, Horse, Bovine, Guinea Pig, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 23kDa |
| Gene ID | 27314 |
|---|---|
| Other Names | Ras-related protein Rab-30, RAB30 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-RAB30 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | RAB30 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RAB30 (HGNC:9770) |
|---|---|
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:22188167). RAB30 is required for maintaining the structural integrity of the Golgi apparatus, possibly by mediating interactions with cytoplasmic scaffolding proteins (PubMed:22188167). Facilitates lipid homeostasis during fasting by regulating hepatic protein and lipid trafficking in a PPAR-alpha-dependent manner (By similarity). Promotes autophagosome biogenesis during bacterial infection such as group A Streptococcus infection (PubMed:26771875). |
| Cellular Location | Membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus, trans- Golgi network membrane. Golgi apparatus, cis-Golgi network membrane. Golgi apparatus membrane. Cytoplasm. Cytoplasmic vesicle, autophagosome membrane. Autolysosome membrane. Note=Localized to dynamic membranes fusing to and exiting from the Golgi apparatus (By similarity) Localized to group A Streptococcus (GAS)-containing autophagosome to autolysosome in GAS-infected epithelial cells (PubMed:26771875). Also colocalized with a starvation-induced autophagosome although not required for autophagosome formation during starvation (PubMed:26771875). {ECO:0000250|UniProtKB:Q923S9, ECO:0000269|PubMed:26771875} |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Chen D.,et al.Gene 174:129-134(1996).
Puhl H.L. III,et al.Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
Halleck A.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Taylor T.D.,et al.Nature 440:497-500(2006).
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$ 389.00
Cat# AI15347
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