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ATP6V0D1 Antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
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- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P61421 |
| Other Accession | NM_004691, NP_004682 |
| Reactivity | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog |
| Predicted | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 39kDa |
| Gene ID | 9114 |
|---|---|
| Alias Symbol | ATP6D, ATP6DV, FLJ43534, P39, VATX, VMA6, VPATPD |
| Other Names | V-type proton ATPase subunit d 1, V-ATPase subunit d 1, 32 kDa accessory protein, V-ATPase 40 kDa accessory protein, V-ATPase AC39 subunit, p39, Vacuolar proton pump subunit d 1, ATP6V0D1, ATP6D, VPATPD |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-ATP6V0D1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | ATP6V0D1 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ATP6V0D1 (HGNC:13724) |
|---|---|
| Synonyms | ATP6D, VPATPD |
| Function | Subunit of the integral membrane V0 complex of the lysosomal proton-transporting V-type ATPase (v-ATPase) (PubMed:28296633, PubMed:30374053). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (PubMed:30374053). May play a role in coupling of proton transport and ATP hydrolysis (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). |
| Cellular Location | Membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane. Note=Localizes to centrosome and the base of the cilium. {ECO:0000250|UniProtKB:Q6PGV1} |
| Tissue Location | Ubiquitous. |
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Provided below are standard protocols that you may find useful for product applications.
References
van Hille B.,et al.Biochem. Biophys. Res. Commun. 197:15-21(1993).
Agarwal A.K.,et al.Biochem. Biophys. Res. Commun. 279:543-547(2000).
Bhat K.S.,et al.Submitted (NOV-1992) to the EMBL/GenBank/DDBJ databases.
Smith A.N.,et al.Gene 297:169-177(2002).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).
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