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B4GALNT2 Antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q8NHY0 |
| Other Accession | NM_153446, NP_703147 |
| Reactivity | Human |
| Predicted | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 62kDa |
| Gene ID | 124872 |
|---|---|
| Alias Symbol | B4GALT, GALGT2, MGC142235, MGC142237 |
| Other Names | Beta-1, 4 N-acetylgalactosaminyltransferase 2, 2.4.1.-, Sd(a) beta-1, 4-GalNAc transferase, UDP-GalNAc:Neu5Aca2-3Galb-R b1, 4-N-acetylgalactosaminyltransferase, B4GALNT2, GALGT2 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-B4GALNT2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | B4GALNT2 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | B4GALNT2 {ECO:0000303|PubMed:30067891, ECO:0000312|HGNC:HGNC:24136} |
|---|---|
| Function | Beta-1,4 N-acetylgalactosaminyltransferase involved in the biosynthesis of Sd(a) histo-blood group antigen. Catalyzes the transfer of N-acetylgalactosamine (GalNAc) group in a beta-1,4-linkage from UDP- GalNAc to the galactose residue of NeuAcalpha2->3Gal-R to form Sd(a) glycan epitope GalNAcbeta1->4(NeuAcalpha2->3)Gal-R. The Sd(a) epitope is carried in O- and N-linked glycoproteins and glycolipids, including O-linked core 1 structures on GYPA/glycophorin, SLC4A1 and SLC29A1 in erythrocytes, N-linked glycans attached to the Tamm-Horsfall glycoprotein UMOD/uromodulin in renal fluids, O-linked core 3 glycans on mucins in colon and neolactosides in gastric mucosa (PubMed:12678917, PubMed:14688233, PubMed:16024623, PubMed:35409292). Confers protection against influenza A virus strains that attach to NeuAcalpha2->3-carrying host receptors. Modifies N-glycan chains on host receptors and prevents virus entry into cells (PubMed:28813663). |
| Cellular Location | [Isoform 1]: Golgi apparatus, trans-Golgi network membrane; Single-pass type II membrane protein. Cytoplasmic vesicle membrane; Single-pass type II membrane protein. Note=Partially colocalizes with EEA1 and LAMP2 in early endosomes and lysosomes, respectively. |
| Tissue Location | Widely expressed. Highly expressed in colon and to a lesser extent in kidney, stomach, ileum and rectum |
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Montiel M.D.,et al.Biochem. J. 373:369-379(2003).
Lo Presti L.,et al.J. Biochem. 134:675-682(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:1045-1049(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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$ 389.00
Cat# AI15420
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