|Other Accession||NM_022968, NP_075257|
|Reactivity||Human, Mouse, Rat, Rabbit, Bovine, Guinea Pig|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Bovine, Guinea Pig|
|Alias Symbol||4F5, FAM2A, H4F5, SERF1, SERF1B, SMAM1|
|Other Names||Small EDRK-rich factor 1, Protein 4F5, h4F5, SMA modifier 1, SERF1A, FAM2A, SERF1, SMAM1|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-SERF1A antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||SERF1A Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||FAM2A, SERF1, SMAM1|
|Function||Positive regulator of amyloid protein aggregation and proteotoxicity (PubMed:20723760, PubMed:22854022, PubMed:31034892). Induces conformational changes in amyloid proteins, such as APP, HTT, and SNCA, driving them into compact formations preceding the formation of aggregates (PubMed:20723760, PubMed:22854022, PubMed:31034892).|
|Cellular Location||Cytoplasm, cytosol. Nucleus|
|Tissue Location||Isoform Long is predominantly expressed in heart, brain and skeletal muscle. Isoform Short and Isoform Long are expressed throughout the central nervous system, including spinal cord|
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