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CCDC134 Antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9H6E4 |
| Other Accession | NM_024821, NP_079097 |
| Reactivity | Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog |
| Predicted | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 25kDa |
| Gene ID | 79879 |
|---|---|
| Alias Symbol | FLJ22349, MGC21013, dJ821D11.3 |
| Other Names | Coiled-coil domain-containing protein 134, CCDC134 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-CCDC134 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | CCDC134 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CCDC134 {ECO:0000303|PubMed:39509507, ECO:0000312|HGNC:HGNC:26185} |
|---|---|
| Function | Molecular adapter required to prevent protein hyperglycosylation of HSP90B1: during translation, associates with nascent HSP90B1 and the STT3A catalytic component of the OST-A complex and tethers them to a specialized translocon that forms a microenvironment for HSP90B1 folding (PubMed:38670073, PubMed:39509507). In the CCDC134-containing translocon, STT3A associates with the SRT pseudosubstrate motif of HSP90B1, preventing access to facultative glycosylation sites until folding is completed, preventing hyperglycosylation and subsequent degradation of HSP90B1 (PubMed:39509507). In extracellular secreted form, promotes proliferation and activation of CD8(+) T-cells, suggesting a cytokine- like function (PubMed:25125657). May inhibit ERK and JNK signaling activity (PubMed:18087676, PubMed:23070808). May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling (PubMed:23070808). May also localize in the nucleus: enhances stability of the PCAF histone acetyltransferase (HAT) complex member TADA2A and thus promotes PCAF-mediated histone acetyltransferase activity (PubMed:22644376). Has a critical role in the regulation of osteogenesis and bone development (PubMed:32181939). |
| Cellular Location | Endoplasmic reticulum lumen. Secreted. Cytoplasm Nucleus. Note=Mainly localizes to the endoplasmic reticulum (PubMed:39509507). Accumulates in the nucleus in response to UV irradiation (PubMed:22644376) |
| Tissue Location | Expressed in cervical gland, cervical squamous epithelium, endometrium, stomach, kidney distal convoluted tubule, spermatogenic cells in testis, mammary gland, liver and striated muscle (at protein level) (PubMed:18087676, PubMed:23070808). Also detected in placenta (PubMed:18087676). Highest expression in testis relative to other tissues (PubMed:18087676). Detected in T cells and dendritic cells; highly expressed in activated CD8(+) T cells, and also expressed at lower levels in CD4(+) T cells (PubMed:25125657) |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Dunham I.,et al.Nature 402:489-495(1999).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).
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$ 389.00
Cat# AI15482
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