|Other Accession||NM_145315, NP_660358|
|Reactivity||Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Other Names||Lactation elevated protein 1, Protein AFG1 homolog, LACE1, AFG1|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-LACE1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||LACE1 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Putative mitochondrial ATPase. Plays a role in mitochondrial morphology and mitochondrial protein metabolism. Promotes degradation of excess nuclear-encoded complex IV subunits (COX4I1, COX5A and COX6A1) and normal activity of complexes III and IV of the respiratory chain (PubMed:26759378, PubMed:27323408). Mediates mitochondrial translocation of TP53 and its transcription-independent apoptosis in response to genotoxic stress (PubMed:27323408).|
|Cellular Location||Mitochondrion membrane|
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Provided below are standard protocols that you may find useful for product applications.
Abrahams B.S.,et al.Genomics 80:45-53(2002).
Mungall A.J.,et al.Nature 425:805-811(2003).
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