|Other Accession||NM_001005511, NP_001005511|
|Reactivity||Human, Mouse, Pig, Bovine, Guinea Pig|
|Predicted||Human, Mouse, Pig, Bovine, Guinea Pig|
|Alias Symbol||BC059845, aatyk3|
|Other Names||Serine/threonine-protein kinase LMTK3, 18.104.22.168, Apoptosis-associated tyrosine kinase 3, Lemur tyrosine kinase 3, Lmtk3, Aatyk3|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Lmtk3 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Lmtk3 Antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (By similarity). Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons (PubMed:24760852).|
|Cellular Location||Membrane; Single- pass membrane protein. Cell projection, axon. Cell projection, dendrite. Golgi apparatus membrane. Note=Punctate pattern in cell projections|
|Tissue Location||Expressed in brain. Predominantly expressed in cerebral cortex, thalamus, the cerebellum and hippocampal formation (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
Tomomura M.,et al.Neuroscience 148:510-521(2007).
Trinidad J.C.,et al.Mol. Cell. Proteomics 5:914-922(2006).
Munton R.P.,et al.Mol. Cell. Proteomics 6:283-293(2007).
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