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RTN4RL1 Antibody - middle region

Rabbit Polyclonal Antibody

     
  • WB - RTN4RL1 Antibody - middle region AI15533

    Host: Rabbit
    Target Name: RTN4RL1
    Sample Tissue: Placenta lysates
    Antibody Dilution: 1.0μg/ml
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q86UN2
Other Accession NM_178568, NP_848663
Reactivity Human, Rabbit, Pig, Horse, Bovine
Predicted Human, Rabbit, Pig, Horse, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 49kDa
Additional Information
Gene ID 146760
Alias Symbol DKFZp547J144, NGRH2, NgR3
Other Names Reticulon-4 receptor-like 1, Nogo receptor-like 2, Nogo-66 receptor homolog 2, Nogo-66 receptor-related protein 3, NgR3, RTN4RL1 (HGNC:21329)
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-RTN4RL1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsRTN4RL1 Antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RTN4RL1 (HGNC:21329)
Function Cell surface receptor. Plays a functionally redundant role in postnatal brain development and in regulating axon regeneration in the adult central nervous system. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG. Plays a role in inhibiting neurite outgrowth and axon regeneration via its binding to neuronal chondroitin sulfate proteoglycans. Binds heparin (By similarity). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200).
Cellular Location Cell membrane; Lipid-anchor, GPI-anchor. Membrane raft. Perikaryon {ECO:0000250|UniProtKB:Q80WD0}. Cell projection {ECO:0000250|UniProtKB:Q80WD0}. Note=Localized to the surface of neurons, including axons. {ECO:0000250|UniProtKB:Q80WD0}
Tissue Location Predominantly expressed in brain. Expressed at lower levels in kidney, lung, mammary gland, placenta, salivary gland, skeletal muscle and spleen.
Research Areas
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References

Lauren J.,et al.Mol. Cell. Neurosci. 24:581-594(2003).
Pignot V.,et al.J. Neurochem. 85:717-728(2003).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Barton W.A.,et al.EMBO J. 22:3291-3302(2003).

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$ 389.00
Cat# AI15533
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