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SAPCD2 Antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q86UD0 |
| Other Accession | NM_178448, NP_848543 |
| Reactivity | Human, Rabbit, Guinea Pig, Dog |
| Predicted | Human, Rabbit, Pig, Guinea Pig, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 43kDa |
| Gene ID | 89958 |
|---|---|
| Alias Symbol | C9orf140, p42.3 |
| Other Names | Suppressor APC domain-containing protein 2, Tumor specificity and mitosis phase-dependent expression protein, TS/MDEP, p42.3, SAPCD2, C9orf140 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-SAPCD2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | SAPCD2 Antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SAPCD2 (HGNC:28055) |
|---|---|
| Synonyms | C9orf140 |
| Function | Plays a role in planar mitotic spindle orientation in retinal progenitor cells (RPCs) and promotes the production of symmetric terminal divisions (By similarity). Negatively regulates the mitotic apical cortex localization of GPSM2 (PubMed:26766442). Involved also in positive regulation of cell proliferation and tumor cell growth (PubMed:23576022, PubMed:23704824). |
| Cellular Location | Cytoplasm. Nucleus. Cytoplasm, cell cortex. Apical cell membrane {ECO:0000250|UniProtKB:Q9D818}. Cell junction, tight junction. Note=Localized at the apical cortical region during the M phase. In horizontally retinal progenitor dividing cells, localized at the pole cortical region from prophase to telophase cells. In vertically retinal progenitor dividing cells, not detected at the pole cortical region at any stage of mitosis {ECO:0000250|UniProtKB:Q9D818} |
| Tissue Location | Expressed in 5-month-old fetal tissues, including stomach, intestine, colon, liver, brain, lung, heart, spleen and kidney (PubMed:17525738). Undetectable in non-cancerous adult tissues (PubMed:17525738). Expressed in many primary gastric carcinoma, but almost not in adjacent normal mucosa (PubMed:17525738). Expressed preferentially in M and G1 phases, compared to S and G2 phases (PubMed:17525738). Expression is up-regulated in hepatocellular carcinoma (HCC) and colorectal cancer (CRC) tissues (at protein level) (PubMed:23704824). |
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 389.00
Cat# AI15567
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