|Other Accession||NM_007944, NP_031970|
|Reactivity||Human, Mouse, Rat, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Pig, Horse, Bovine, Guinea Pig, Dog|
|Alias Symbol||9830147J04Rik, AI593686, Eps15-rs, Eps15R|
|Other Names||Epidermal growth factor receptor substrate 15-like 1, Epidermal growth factor receptor pathway substrate 15-related sequence, Eps15-rs, Eps15-related protein, Eps15R, Eps15l1, Eps15-rs, Eps15R|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Eps15l1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Eps15l1 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2 (By similarity).|
|Cellular Location||Cell membrane; Peripheral membrane protein. Nucleus. Membrane, coated pit. Note=Localized to plasma membrane coated pits|
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Provided below are standard protocols that you may find useful for product applications.
Wong W.T.,et al.Proc. Natl. Acad. Sci. U.S.A. 92:9530-9534(1995).
Carninci P.,et al.Science 309:1559-1563(2005).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Coda L.,et al.J. Biol. Chem. 273:3003-3012(1998).
Rush J.,et al.Nat. Biotechnol. 23:94-101(2005).
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