|Other Accession||NM_001017990, NP_001017990|
|Other Names||Histone H2A-Bbd type 1, H2A Barr body-deficient, H2A.Bbd, H2AFB1|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-H2AFB1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||H2AFB1 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing (PubMed:22795134). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability (PubMed:15257289, PubMed:16287874, PubMed:16957777, PubMed:17591702, PubMed:17726088, PubMed:18329190, PubMed:22795134). Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo (PubMed:15257289, PubMed:16957777, PubMed:17591702, PubMed:24336483). They are enriched in actively transcribed genes and associate with the elongating form of RNA polymerase (PubMed:17591702, PubMed:24753410). They associate with spliceosome components and are required for mRNA splicing (PubMed:22795134).|
|Cellular Location||Nucleus. Chromosome Note=Associated with the active X chromosome and with autosomes, while it is absent from the inactive X chromosome and excluded from Barr bodies.|
|Tissue Location||Present in mature sperm.|
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Provided below are standard protocols that you may find useful for product applications.
Naylor J.A.,et al.Hum. Mol. Genet. 4:1217-1224(1995).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Ross M.T.,et al.Nature 434:325-337(2005).
Bao Y.,et al.EMBO J. 23:3314-3324(2004).
Okuwaki M.,et al.Mol. Cell. Biol. 25:10639-10651(2005).
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