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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   Ccdc47 Antibody - C-terminal region   

Ccdc47 Antibody - C-terminal region

Rabbit Polyclonal Antibody

     
  • WB - Ccdc47 Antibody - C-terminal region AI15658

    Host: Rabbit
    Target Name: Ccdc47
    Sample Tissue: Mouse Liver lysates
    Antibody Dilution: 1.0μg/ml
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q9D024
Other Accession NM_026009, NP_080285
Reactivity Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog
Predicted Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 53kDa
Additional Information
Gene ID 67163
Alias Symbol 2610204L23Rik, C88307, RP23-81G14.10, asp4, calumin
Other Names Coiled-coil domain-containing protein 47, Adipocyte-specific protein 4, Ccdc47, Asp4
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-Ccdc47 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsCcdc47 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Ccdc47 {ECO:0000312|MGI:MGI:1914413}
Function Component of the PAT complex, an endoplasmic reticulum (ER)- resident membrane multiprotein complex that facilitates multi-pass membrane proteins insertion into membranes. The PAT complex acts as an intramembrane chaperone by directly interacting with nascent transmembrane domains (TMDs), releasing its substrates upon correct folding, and is needed for optimal biogenesis of multi-pass membrane proteins. WDR83OS/Asterix is the substrate-interacting subunit of the PAT complex, whereas CCDC47 is required to maintain the stability of WDR83OS/Asterix. The PAT complex favors the binding to TMDs with exposed hydrophilic amino acids within the lipid bilayer and provides a membrane-embedded partially hydrophilic environment in which the first transmembrane domain binds. Component of a ribosome-associated ER translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis. Involved in the regulation of calcium ion homeostasis in the ER. Required for proper protein degradation via the ERAD (ER-associated degradation) pathway (By similarity). Has an essential role in the maintenance of ER organization during embryogenesis (PubMed:25009997).
Cellular Location Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q96A33}; Single-pass membrane protein. Rough endoplasmic reticulum membrane
Tissue Location In the embryo, expressed in the endodermal layer of the yolk sac and in the small intestine.
Research Areas
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References

Tsuruga H.,et al.Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
Carninci P.,et al.Science 309:1559-1563(2005).
Church D.M.,et al.PLoS Biol. 7:E1000112-E1000112(2009).

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$ 389.00
Cat# AI15658
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