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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   ENPP7 Antibody - N-terminal region   

ENPP7 Antibody - N-terminal region

Rabbit Polyclonal Antibody

  • WB - ENPP7 Antibody - N-terminal region AI15813

    Host: Rabbit
    Target Name: ENPP7
    Sample Tissue: 721_B Whole cell lysate
    Antibody Dilution: 1.0μg/ml
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q6UWV6
Other Accession NM_178543, NP_848638
Reactivity Human, Mouse, Rat
Predicted Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 49kDa
Additional Information
Gene ID 339221
Alias Symbol ALK-SMase
Other Names Ectonucleotide pyrophosphatase/phosphodiesterase family member 7, E-NPP 7, NPP-7,, Alkaline sphingomyelin phosphodiesterase, Intestinal alkaline sphingomyelinase, Alk-SMase, ENPP7 {ECO:0000312|EMBL:AAH41453.2}
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-ENPP7 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsENPP7 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ENPP7 {ECO:0000312|EMBL:AAH41453.2, ECO:0000312|HGNC:HGNC:23764}
Function Choline-specific phosphodiesterase that hydrolyzes sphingomyelin releasing the ceramide and phosphocholine and therefore is involved in sphingomyelin digestion, ceramide formation, and fatty acid (FA) absorption in the gastrointestinal tract (PubMed:12885774, PubMed:12671034, PubMed:15205117, PubMed:16255717, PubMed:28292932). Has also phospholipase C activity and can also cleave phosphocholine from palmitoyl lyso-phosphatidylcholine and platelet-activating factor (PAF) leading to its inactivation (PubMed:16255717, PubMed:12885774). Does not have nucleotide pyrophosphatase activity (PubMed:12885774). May promote cholesterol absorption by affecting the levels of sphingomyelin derived from either diet or endogenous sources, in the intestinal lumen (By similarity).
Cellular Location Cell membrane; Single-pass type I membrane protein. Note=The catalytic domain is released into the extracellular medium when cells are treated with trypsin (PubMed:15205117). Localized at the surface of the microvillar membrane in small intestine enterocytes, and in endosome-like structures situated beneath the microvillar membrane, and in Golgi complex (PubMed:12671034, PubMed:12885774)
Tissue Location Detected in the colon (at protein level). Expressed in the duodenum, jejunum and liver and at low levels in the ileum Expression was very low in the esophagus, stomach and colon
Research Areas
Citations (0)

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Converts sphingomyelin to ceramide. Also has phospholipase C activity toward palmitoyl lyso-phosphocholine. Does not appear to have nucleotide pyrophosphatase activity.


Duan R.-D.,et al.J. Biol. Chem. 278:38528-38536(2003).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zhang Z.,et al.Protein Sci. 13:2819-2824(2004).
Duan R.-D.,et al.J. Lipid Res. 44:1241-1250(2003).

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$ 389.00
Cat# AI15813
Availability: 2-3 days
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