|Other Accession||NM_024326, NP_077302|
|Reactivity||Human, Mouse, Rat, Rabbit, Horse, Bovine, Neisseria Gonorrhoeae, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Horse, Bovine, Neisseria Gonorrhoeae, Dog|
|Alias Symbol||FBXO37, Fbl15, JET, PSD|
|Other Names||F-box/LRR-repeat protein 15, F-box only protein 37, FBXL15, FBXO37|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-FBXL15 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||FBXL15 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2.|
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Provided below are standard protocols that you may find useful for product applications.
Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2.
Deloukas P.,et al.Nature 429:375-381(2004).
Cui Y.,et al.EMBO J. 30:2675-2689(2011).
Van Damme P.,et al.Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
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