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FBXL15 Antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9H469 |
| Other Accession | NM_024326, NP_077302 |
| Reactivity | Human, Mouse, Rat, Rabbit, Horse, Bovine, Neisseria Gonorrhoeae, Dog |
| Predicted | Human, Mouse, Rat, Rabbit, Horse, Bovine, Neisseria Gonorrhoeae, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 32kDa |
| Gene ID | 79176 |
|---|---|
| Alias Symbol | FBXO37, Fbl15, JET, PSD |
| Other Names | F-box/LRR-repeat protein 15, F-box only protein 37, FBXL15, FBXO37 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-FBXL15 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | FBXL15 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FBXL15 |
|---|---|
| Synonyms | FBXO37 |
| Function | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2. |
| Cellular Location | Cytoplasm. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2.
References
Deloukas P.,et al.Nature 429:375-381(2004).
Cui Y.,et al.EMBO J. 30:2675-2689(2011).
Van Damme P.,et al.Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
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