|Other Accession||NM_014773, NP_055588|
|Reactivity||Human, Horse, Bovine|
|Predicted||Human, Horse, Bovine|
|Other Names||Death ligand signal enhancer, KIAA0141, DELE|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-KIAA0141 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||KIAA0141 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||[DAP3-binding cell death enhancer 1]: Key activator of the integrated stress response (ISR) following mitochondrial stress (PubMed:32132706, PubMed:32132707). In response to mitochondrial stress, cleaved by the protease OMA1, generating the DAP3-binding cell death enhancer 1 short form (DELE1(S) or S-DELE1), which translocates to the cytosol and activates EIF2AK1/HRI to trigger the ISR (PubMed:32132706, PubMed:32132707). Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation (PubMed:20563667).|
|Cellular Location||[DAP3-binding cell death enhancer 1]: Mitochondrion Mitochondrion inner membrane Note=Associates with the mitochondrion inner membrane in response to mitochondrial stress, leading to its proteolytic processing by OMA1, and generation of the AP3-binding cell death enhancer 1 short form (DELE1(S) or S-DELE1).|
|Tissue Location||Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation.
Nagase T.,et al.DNA Res. 2:167-174(1995).
Harada T.,et al.Apoptosis 15:1247-1255(2010).
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