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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   KIAA0141 Antibody - N-terminal region   

KIAA0141 Antibody - N-terminal region

Rabbit Polyclonal Antibody

     
  • WB - KIAA0141 Antibody - N-terminal region AI15861

    Host: Rabbit
    Target Name: KIAA0141
    Sample Tissue: HepG2 Whole cell lysate
    s
    Antibody Dilution: 1.0μg/mlKIAA0141 is supported by BioGPS gene expression data to be expressed in HepG2
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q14154
Other Accession NM_014773, NP_055588
Reactivity Human, Horse, Bovine
Predicted Human, Horse, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 45kDa
Additional Information
Gene ID 9812
Alias Symbol DELE
Other Names Death ligand signal enhancer, KIAA0141, DELE
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-KIAA0141 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsKIAA0141 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DELE1 (HGNC:28969)
Function [DAP3-binding cell death enhancer 1]: Key activator of the integrated stress response (ISR) following mitochondrial stress (PubMed:32132706, PubMed:32132707). In response to mitochondrial stress, cleaved by the protease OMA1, generating the DAP3-binding cell death enhancer 1 short form (DELE1(S) or S-DELE1), which translocates to the cytosol and activates EIF2AK1/HRI to trigger the ISR (PubMed:32132706, PubMed:32132707). Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation (PubMed:20563667).
Cellular Location [DAP3-binding cell death enhancer 1]: Mitochondrion Mitochondrion inner membrane Note=Associates with the mitochondrion inner membrane in response to mitochondrial stress, leading to its proteolytic processing by OMA1, and generation of the AP3-binding cell death enhancer 1 short form (DELE1(S) or S-DELE1).
Tissue Location Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon
Research Areas
Citations (0)

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Background

Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation.

References

Nagase T.,et al.DNA Res. 2:167-174(1995).
Harada T.,et al.Apoptosis 15:1247-1255(2010).

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$ 389.00
Cat# AI15861
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